EXHIBIT 16.1 [Letterhead of NUSSBAUM YATES & WOLPOW, P.C.] March 28, 2005 Securities and Exchange Commission 450 Fifth Street, N.W. Washington, D.C. 20549 Re: Pacific Ethanol, Inc. Commission File Number 000-21467 Commissioners: We have read the statements made by Pacific Ethanol, Inc. under item 4.01, Changes in Registrant's Certifying Accountant, which we understand will be filed with the Commission, pursuant to Item 4.01 of Form 8-K, as part of the Company's Form 8-K report dated March 23, 2005. We agree with the statements concerning our Firm in such Form 8-K. Very truly yours, /s/ NUSSBAUM YATES & WOLPOW, P.C. --------------------------------- Nussbaum Yates & Wolpow, P.C.